Overview
Dr. Viny is an assistant professor of medicine at Columbia University Vagelos College of Physician and Surgeons. He is a hematologist and medical oncologist and laboratory-based physician-scientist focusing on the study of clonal hematopoiesis, myelodysplastic syndrome, and acute myeloid leukemias. His research uses state-of-the-art 3-dimensional genomic techniques to uncover the genetic and epigenetic underpinnings of these diseases in order to find more precise and less toxic treatment modalities.
Dr. Viny received his medical degree at Cleveland Clinic Lerner College of Medicine at Case Western Reserve University and completed his residency in Internal Medicine at New York-Presbyterian/Weill Cornell Medical College and fellowship in Hematology and Medical Oncology at Memorial Sloan Kettering Cancer Center.
Areas of Expertise / Conditions Treated
- Acute Leukemia
- Acute Myeloid Leukemia
- Hematologic Malignancies
- Myelodysplastic Syndrome
- Myeloproliferative Disease
- Myeloproliferative Neoplasms
Academic Appointments
- Assistant Professor of Medicine
Administrative Titles
- Assistant Professor of Genetics & Development
- Member, Columbia Stem Cell Initiative
- Member, Cancer Genomics and Epigenomics Program, Herbert Irving Comprehensive Cancer Center
Gender
- Male
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Insurance Accepted
Aetna
- Aetna Signature Administrators
- NYP Employee Plan
- NY Signature
- Student Health
Affinity Health Plan
- Medicaid Managed Care
AgeWell
- Medicare Managed Care
- Special Needs
Cigna
- EPO
- Great West (National)
- HMO
- Medicare Managed Care
- POS
- PPO
Emblem/GHI
- Medicare Managed Care
- PPO
Emblem/HIP
- ConnectiCare
- EPO
- Essential Plan
- HMO
- Medicare Managed Care
- POS
- PPO
- Select Care (Exchange)
- Vytra
Empire Blue Cross/Blue Shield
- EPO
- PPO
Empire Blue Cross Blue Shield HealthPlus
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
Fidelis Care
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
Healthfirst
- Child/Family Health Plus
- Leaf (Exchange)
- Medicaid Managed Care
- Medicare Managed Care
Local 1199
- Local 1199
MagnaCare (National)
- MagnaCare
Medicare
- Railroad
- Traditional Medicare
Multiplan
- Multiplan
MVP Health Care
- Child/Family Health Plus
- Essential Plan
- HMO
- Medicaid Managed Care
Quality Health Management
- Quality Health Management
RiverSpring
- Special Needs
UnitedHealthcare
- Compass (Exchange)
- Empire Plan
- HMO
- Medicaid (Community Plan)
- Oxford Freedom
- Oxford HMO
- Oxford Liberty
- POS
- PPO
VNSNY CHOICE
- SelectHealth
- Special Needs
WellCare
- Medicare Managed Care
- New Jersey Services (Medicaid Managed Care)
World Trade Center Health Plan
- World Trade Center Health Plan
Credentials & Experience
Education & Training
- Cleveland Clinic Lerner College of Medicine at Case Western Reserve University
- Internship: New York Presbyterian/Weill Cornell Medical College
- Residency: New York Presbyterian/Weill Cornell Medical College
- Fellowship: Memorial Sloan Kettering Cancer Center
Board Certifications
- Medical Oncology
- Hematology
- Internal Medicine
Honors & Awards
- Louis V. Gerstner Jr. Scholar, Columbia University Irving Medical Center 2021
- ASH Scholar Award, American Society of Hematology 2021
- Paul Sherlock Housestaff Teaching Award, Memorial Sloan Kettering Cancer Center 2020
- Young Physician Scientist Award, American Society of Clinical Investigation 2020
- Young Investigator Award, Edward P. Evans Foundation 2019
- William Raveis Charitable Fund Fellowship, Damon Runyon Cancer Research Foundation 2016
- Young Investigator Award, American Society of Clinical Oncology 2015
- ASH RTAF Award, American Society of Hematology 2014
- David E. Rogers Memorial Research Award, NYP/Weill Cornell Medical College 2012
- Joseph G. Hayes Senior Resident Teaching Award, NYP/Weill Cornell Medical College 2012
- CARE Award, New York Presbyterian Hospitals of Columbia and Cornell 2011
Research
Normal gene expression is controlled, in part, through multiple regulatory systems which coordinate transcription. This includes transcription factors that recruit enzymes to express genes as well as an evolving understanding of the 3-dimensional chromatin architecture which brings together either DNA enhancer regions to activate genes or DNA insulation regions to silence genes. Structural scaffold proteins such at CTCF and the cohesin complex are essential in maintaining the integrity of local DNA structural interactions within defined neighborhoods known as topologically associating domains (TADs).
These proteins provide dynamic structure within the TAD which is essential in influencing dynamic cell-type specific transcriptional programs. Genes which contribute to transcriptional regulation, including members of the cohesin complex, are frequently mutated in human cancers, including acute myeloid leukemia (12-20%), glioblastoma multiforme (5%), bladder cancer (20-35%) and Ewing sarcoma (40-50%).
The functional consequences of chromatin structure in regulating lineage-specification, signal-dependent responses, and local/distant DNA structure has not been fully elucidated, however, our recent work has established the requirement of suitable chromatin architecture for the function of cell-type specific transcription factors to activate gene responsible for blood formation bone marrow stem cell differentiation.
Our laboratory uses genetic mouse models and primary patient samples to understand the role of altered chromatin architecture as a regulator of gene expression/gene silencing that maintain the balance of hematopoietic stem cell self-renewal with differentiation and blood formation.
Grants
NIH/NCI K08 CA215317, “Role of the Cohesin complex in normal and malignant hematopoiesis” 8/2018-7/2023
Edward P. Evans Foundation Young Investigator Award, “Cohesin complex mutations decouple chromatin structure and transcriptional output in myelodysplastic syndrome” 7/2018-6/2021
Selected Publications
Viny AD,Levine RL.Drug Modulation by Nuclear Condensates.Science. 2020 Jun 19; 6497(368): 1314-1315.
Kishtagari A, Levine RL,VinyAD.Driver Mutations in Acute Myeloid Leukemia.Curr Opin Hematol. 2020 March;27(2): 49-57. PMID: 31972687
Viny AD,Bowman RL, Liu Y, Lavallée VP, Eisman S, Xiao W, Durham B, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe’er D, Dekker J, Koche R, Levine RL.Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation.Cell Stem CellNovember 7, 25(5): 682-696 e688. PMID: 31495782
Viny AD, Levine RL.Cohesin mutations in myeloid malignancies made simple.Curr Opin Hematol. 2017 Dec 22. PubMed PMID: 29278534
Viny AD, Levine RL.Roads Diverge--A Robert Frost View of Leukemia Development.N Engl J Med. 2016 Jun 9;374(23):2282-4. PubMed PMID: 27276567.
van Galen P,Viny AD, Ram O, Ryan RJH, Cotton MJ, Donohue L, Sievers C, Drier Y, Liau BB, Gillespie SM, Carroll KM, Cross MB, Levine RL, Bernstein BE.A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.Molecular Cell. 2016 Jan 7 PMID:26687680
Viny AD*,Ott CJ*, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL.Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.Journal of Experimental Medicine, 2015 Oct 5 PMID: 2648361.
- Thota S*,Viny AD*, Makishima H, Spitzer B, Radivoyevitch T, Przychodzen B, Sekeres MA, Levine RL, Maciejewski JP.Genetic alterations of the cohesin complex genes in myeloid malignancies,Blood,2014 Sept 11;124(11): 1790-8. PMID: 25006131
Related News
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Source:
HICCCFebruary 16, 2021
